TLR–CD40 Cross-Talk in Anti-Leishmanial Immune Response

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TLR–CD40 Cross-Talk in Anti-Leishmanial Immune Response

Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns (PAMPs) and activate innate immune cells to induce cytokines and co-stimulatory molecules such as CD40 and to enhance antigen presentation to T cells (1) that, upon activation, can either eliminate or support the pathogen (2). Herein, we propose that this duality in TLR functions results from their cross-talk with CD40....

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ژورنال

عنوان ژورنال: Frontiers in Immunology

سال: 2014

ISSN: 1664-3224

DOI: 10.3389/fimmu.2014.00220